Mystery Solvers are groups of humans who solved mysteries.
| ||The Hunters of Secrets (also known as the Ma Cuben Sun Macul) were the first mystery solving group in existence, about the 1000s. They looked similar to Mystery Incorporated. They possessed a valuable treasure.|
| ||The Fraternitas Mysterium were all men but are monks and was active in the 1500s, around the time of the conquistadors. In the end of Fraternitas Mysterium, all of them fought over two odd-shaped pieces and died but their leader.|
The Alianza Misterio
|The Alianza Misterio were four Mexican mystery-solvers in the 1600s with their zorro-styled masks. Their skunk mascot even wore one. They possessed the Tercero Llave.|
The Mystery Gang
|The Mystery Gang is were four cowgirl mystery solvers in the 1700s. They possessed the Segundo Llave.|
The Benevolent Lodge
|The Benevolent Lodge of Mystery were active in the 1880s, and were the smartest known mystery solvers in the world. Abigail Gluck, the brains of the gang, was known as the creator of the Kriegstaffebots. They formerly possessed the Cuarto Llave.|
| ||The Darrow Family are a mystery family/solving group in the 1900s. Just like Fraternitas Mysterium, the end of their gang triggered due to fighting over the Planispheric Disk, making the Darrow Mansion sink underground. They formerly possessed the Primero Llave.|
| ||Mystery Incorporated are the incorporation ever to be heard/seen in the world. They (except Cassidy Williams) were the enemies of the new gang of the same name. After Nibiru, they worked together.|
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